A Deeper Look At Cystic Fibrosis Sciences Essays

A Deeper Look At Cystic Fibrosis Sciences Essays A Deeper Look At Cystic Fibrosis Sciences Essay A Deeper Look At Cystic Fibrosis Sciences Essay A ; Doring, G. ( 2003 ) . Cystic fibrosis.Lancet, 361, 681-689. This paper is a review paper depicting Cystic Fibrosis. It reveals of import statistics about Cystic Fibrosis. It besides describes some possible intervention options. Sheppard, D.N. , A ; Welsh, M.J. ( 1999 ) . Structure and map of the CFTR chloride channel.Physiological Reviews, 79, 23-45. This is a reappraisal article depicting the construction and map of CFTR in item. Provides and describes the biophysical belongingss and composing of CFTR protein. Gallic, P.J. , Doorninck, J.H. , Peters, R.H. , Verbeek, E. , Ameen, N.A. , Marino, C.R. , Jonge, H.R. , Bijman J. A ; Scholte B.J. ( 1996 ) . A delta F508 mutant in mouse cystic fibrosis transmembrane conductance regulator consequences in a temperature-sensitive processing defect in vivo. Journal of Clinical Investigation, 98, 1304-1312 This article describes the belongingss of the delta F508 mutant in mouse. It shows the correlativity between protein map and the mutant in CFTR. Wang, X. , Moylan, B. , Leopold, D.A. , Kim, J. , Rubenstein, R.C. , Togias, A. , Proud, D. , Zeitlin, P.L. , A ; Cutting, G.R. ( 2000 ) . Mutant in the cistron responsible for cystic fibrosis and sensitivity to chronic rhinosinusitis in the general population. Journal of the American Medical Association, 284 ( 14 ) , 1814-9. This article describes the mutant of CFTR cistrons by different mutants. It points to a common sensitivity to chronic rhinosinusitis in persons with mutants. Wang, Y. , Loo, T.W. , Bartlett, M.C. , A ; Clarke, D.M. ( 2007 ) . Correctors promote ripening of cystic fibrosis transmembrane conductance regulator ( cystic fibrosis transport regulator ) -processing mutations by adhering to the protein.The Journal of Biological Chemistry,282 ( 46 ) , 33247-33251. This article describes the misfolds in a CFTR protein and its consequence on the protein map. It besides provides some possible techniques for handling CF utilizing protein correctors and by bring oning farther mutants. Norez, C. , Pasetto, M. , Dechecchi, M.C. , Barison, E. , Anselmi, C. , Tamanini, A. , Quiri, F. , Cattel, L. , Rizzotti, P. , Dosio, F. , Cabrini, G. A ; Colombatti, M. ( 2008 ) . Chemical junction of deltaF508-CFTR corrector deoxyspergualin to transporter human serum albumen enhances its ability to deliver Cl- channel maps. American Journal of Physiology, 295, 336-347. This article describes the a possible chemical corrector which when used in concurrence to the serum albumen, enhances mutated CFTR map Noel, S. , Wilke, M. , Bot, A.G.M. , De Jonge, H.R. , A ; Becq, F. ( 2008 ) . Parallel betterment of Na and chloride conveyance defects by miglustat ( n-butyldeoxynojyrimicin ) in cystic fibrosis epithelial cells.The Journal of Pharmacology and Experimental Therapetics, 325 ( 3 ) , 1016-1023. This article describes the consequence of Miglustat in bettering the operation of Na and chloride ion transporters. Chan, H.S. , A ; Ruan, Y.C. , et.al. ( 2008 ) . The Cystic fibrosis transmembrane conductance regulator in generative wellness and disease.The Journal of Physiology, 587, 2187-2195. This article shows that CF patients potentially suffer from sterility or subfertility due to blockage of generative piece of land by syrupy mucous secretion. McCallum, T.J. , Milunsky, J.M. , Cunningham, D.L. , Harris, D.H. , Maher, T.A. A ; Oates, R.D. ( 2000 ) . Birthrate in work forces with cystic fibrosis: an update on current surgical patterns and results. Chest, 118 ( 4 ) , 1059-1062. This article describes the birthrate in work forces with CF. It shows that work forces with CF have absence of a Vas Deferens due to blockage by mucous secretion. It besides describes some possible surgery techniques which could partly handle this status. Quinton, P.M. ( 2007 ) . Cystic fibrosis: lessons from the perspiration gland.Physiology, 22 ( 3 ) , 212-225. This article describes the correlativity of salty perspiration with Cystic Fibrosis. It shows the importance of salty perspiration as one of the primary sensors of CF in an early phase. Norez, C. , Antigny, F. , Noel, S. , Vandebrouck, C. , A ; Becq, F. ( 2009 ) . A Cystic fibrosis respiratory epithelial cell inveterate treated by miglustat acquires a non-cystic fibrosis-like phenotype.American Journal of Respiratory Cell and Molecular Biology, 41, 217-225. This article describes the consequence of Miglustat drug therapy on CF patients. It shows that after a short sum of intervention in low doses, the result of CF-affected significantly improves and they start acting like non-CF affected cells. Bertrand, J. , Boucherle, B. , Billet, A. , Melin-Heschel, P. , Dannhoffer, L. , Vandebrouck, C. , Jayle, C. , Routaboul, C. , Molina, M.C. , D A ; eacute ; cout, J.L. , Becq, F. , A ; Norez, C. ( 2010 ) Designation of a fresh H2O soluble activator of wild-type and F508delCFTR: GPact-11a. European Respiratory Journal. doi:10.1183/09031936.00122509. ( published online ) This article describes a possible intervention with GPact-11a. It shows that GPact-11a is an activator of CFTR in several airway epithelial lines and activates CFTR in rhinal, tracheal, bronchial and pancreatic cell lines in worlds Rafferty, S. , A ; Alcolado, N. ( 2009 ) . Rescue of functional f508del cystic fibrosis transmembrane conductance regulator by vasoactive enteric peptide in the human rhinal epithelial cell line jme/cf15.The Journal of Pharmacology and Experimental Therapeutics, 331 ( 1 ) , 2-13. This article describes the possible intervention of CF via VIP ( vasoactive enteric peptide ) . The article shows the VIP is utile in increasing the escape of chloride ions from the cells. VIP was besides found to assist in ripening and membrane-insertion of mutated CFTR protein.